Publication: Ultrastructural study of inflammatory bowel disease
Authors
Mughal, S. ; Filipi, M.I.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Ultrastructural changes that occurred in
chronic active ulcerative colitis and Crohn's disease
were investigated and compared to normal as well as to
higher grades of dysplasia in adenomas and carcinomas.
A greater number of immature absorptive cells,
undifferentiated and intermediate cells were seen as
compared to normal. One case of Crohn's and two cases
of chronic ulcerative colitis including one with
coexisting carcinoma showed increased number of
vesicles and electron-dense bodies (EDB) in the
absorptive cells and increased heterogeneity of mucin
droplets in goblet cells and presence of atypical
secretory cells (ASC). Higher grades of dysplasia
characterised by large numbers of atypical secretory
cells were not seen in the present series and provide no
relationship between the atypical ultrastructural features
and increased risk of malignancy. However, the number
of cases investigated is too small and a large series is
required to clarify the significance of observations such
as increased number of electron-dense bodies and
vesicles in the apical cytoplasm and presence of atypical
secretory cells.
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Citation
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