Publication:
“Vascular tuft sign” in neuroendocrine tumors of the pancreas

Simple item page
dc.contributor.authorDíaz Flores, L.
dc.contributor.authorGutiérrez, R.
dc.contributor.authorGarcía Suárez, M.P.
dc.contributor.authorGonzález Gómez, M.
dc.contributor.authorCarrasco, J.L.
dc.contributor.authorMadrid, J. F.
dc.contributor.authorDíaz Flores Jr, L.
dc.date.accessioned2024-10-10T10:07:32Z
dc.date.available2024-10-10T10:07:32Z
dc.date.issued2024
dc.description.abstractThe often well-developed microvasculature in pancreatic neuroendocrine tumors (PanNETs) has been studied from different perspectives. However, some detailed structural findings have received less attention. Our objective is to study an overlooked event in PanNETs: “enclosed vascular tufts” (EVTs). For this purpose, 39 cases of PanNETs were examined with conventional (including serial sections) and immunochemistry procedures. In typical EVTs, the results show: 1) an insulated terminal vascular area, with a globular (glomeruloid) aspect, formed by a cluster of coiled microvessels, presenting CD31-, CD34-positive endothelial cells, αSMA-positive pericytes, and perivascular CD34-positive stromal cells/telocytes, separated by a pseudoglandular space from the surrounding trabeculae of tumor neuroendocrine cells; and 2) a pedicle joining the insulated terminal vascular area, with connective tissue tracts around the enclosing tumor trabeculae. EVTs predominate in the trabecular and nested gyriform pattern of PanNETs, with tumor trabeculae that follow a ribbon coil (winding ribbon pattern) around small vessels, which acquire a tufted image. In EVTs, secondary modifications may occur (fibrosis, hyalinization, myxoid changes, and calcification), coinciding or not with those of the connective tracts. In conclusion, the typical characteristics of unnoticed EVTs allow them to be considered as a morphological sign of PanNETs (a vascular tuft sign). Further in-depth studies are required, mainly to assess the molecular pathways that participate in vascular tuft formation and its pathophysiological implicationses
dc.formatapplication/pdfes
dc.format.extent16es
dc.identifier.doihttps://doi.org/10.14670/HH-18-787
dc.identifier.eisbnHistology and Histopathology Vol. 39, nº11 (2024)es
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/144851
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPancreases
dc.subjectNeuroendocrine tumorses
dc.subjectCD34-positive stromal cells/telocyteses
dc.subjectαSMA-positive myofibroblastses
dc.subjectVascular tuft signes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.title“Vascular tuft sign” in neuroendocrine tumors of the pancreases
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Diaz-Flores-39-1457-1472-2024.pdf
Size:
4.92 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology Vol.39,nº11 (2024)