Publication: Low-grade gliomas clinical and pathobiological aspects
Authors
Smits, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The optimal management of patients with
low-grade gliomas remains a challenge for the treating
physician. The natural history of the disease shows a
large variety, and there is a substantial controversy about
many of everyday treatment recommendations.
H o w e v e r, new developments in clinical and basic
research in neuro-oncology have occurred during the last
years. In this review some of these new insights into
clinical and biological aspects of low-grade gliomas are
discussed, with focus on the translation of new
knowledge from basic research into clinical practice. For
example, molecular genetic profiling of tumour material
has started to guide treatment recommendations and
clinical management of some patients with
oligodendrogliomas. Experimental studies of the
different molecular pathways in tumour cells and in their
normal counterparts involved in cell-cycle check-point
control have elucidated some of the underlying
mechanisms of resistance of gliomas to radiotherapy and
c h e m o t h e r a p y. Finally, improved classification of the
d i fferent subtypes of low-grade gliomas may be
achieved in the near future by characterization of the
genetic heterogeneity within the tumour and by
identification of a putative stem cell as the origin of the
tumour cells.
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