Publication: Spleen and bone marrow megakaryocytes as targets for inhaled vanadium
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Date
2008
Authors
Fortoul, Teresa I. ; Piñón-Zarate, Gabriela ; Diaz-Bech, María Eugenia ; González-Villalva, Adriana ; Mussali-Galante, Patricia ; Rodriguez-Lara,Vilaney ; Colin-Barenque, Laura ; Martinez Pedraza, Michelle ; Montaño, Luis F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
An increased incidence in ischemic and
thromboembolic events in the population of cities with
rising air suspended particle pollution has suggested the
interaction of some of the components of these particles
in the coagulation system. A previous report from our
laboratory identified thrombocytosis as a consequence of
the subacute and chronic inhalation of vanadium. With
this preceding information we decided to evaluate the
effects of this element in the spleen and bone marrow in
a mouse experimental model. CD-1 male mice inhaled
V2O5 0.02 M for one hour twice a week for twelve
weeks. The spleen and bone marrow were processed for
light microscopy. The increase in quantity and size of
megakaryocytes (MKs) in the exposed group in both
organs was striking. Also, modifications in the
cytoplasm, granule content and nuclear ultrastructure
were evident. Our results indicate the influence of
vanadium on megakaryopoyesis, an effect which could
be the onset of the thrombocytosis previously reported
by our group. The modifications in MKs described here
suggest that inhaled vanadium could induce
megakaryocytic proliferation, which may result in
increased production of platelets and increased risk for
thromboembolic events.
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