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Associations between urinary concentrations of bisphenol A and sperm DNA fragmentation in young men.

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dc.contributor.authorKiwitt Cárdenas, Jonathan
dc.contributor.authorAdoamnei, Evdochia
dc.contributor.authorArense Gonzalo, Julián J.
dc.contributor.authorSarabia Cos, Laura
dc.contributor.authorVela Soria, Fernando
dc.contributor.authorFernández, Mariana F.
dc.contributor.authorGonsálvez, Jaime
dc.contributor.authorMendiola Olivares, Jaime
dc.contributor.authorTorres Cantero, Alberto M.
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-11T11:02:33Z
dc.date.available2024-07-11T11:02:33Z
dc.date.issued2021-08
dc.description© 2021 Elsevier Inc. This document is the Published version of a Published Work that appeared in final form in Environmental Research. To access the final edited and published work see https://doi.org/10.1016/j.envres.2021.111289
dc.description.abstractBackground: Bisphenol A (BPA) is one of the most common endocrine disruptor compounds in our environment, promoting a xenoestrogenic state. Numerous studies have shown a relationship between exposure to BPA and male infertility problems. Spermatic DNA integrity is a critical factor for the correct transmission of paternal genetic material to the embryo. However, only a very few studies have investigated the association between urinary BPA concentrations and human sperm DNA fragmentation (SDF). Method: Cross-sectional study conducted with 158 healthy university students (18–23 years), recruited between 2010 and 2011 in the Region of Murcia (Spain). The subjects provided urine and semen samples on a single day. Urinary BPA concentrations were measured by dispersive liquid–liquid microextraction and ultrahigh performance liquid chromatography with tandem mass spectrometry detection, and SDF analysed using the Sperm Chromatin Dispersion test. Statistical analyses were made using linear regression adjusting for potential covariates and confounding factors. Results: No association was found between urinary BPA concentrations and SDF index in the total group. However, in the subgroup of men with SDF index> 30%, significant positive associations across quartiles (ptrend= 0.02) and as a continuous BPA levels were observed (β = 0.055, 95%, CI: 0.002; 0.108). Conclusion: Our results show that, within the subgroup of men with relatively high SDF index, the higher the concentration of BPA the greater the SDF index. Nonetheless, more studies are required to confirm these results and draw conclusions in other male populations.es
dc.embargo.terms1-ene-2999
dc.formatapplication/pdfes
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dc.identifier.citationEnvironmental Research, 2021, Vol. 199: 111289
dc.identifier.doihttps://doi.org/10.1016/j.envres.2021.111289
dc.identifier.issnPrint: 0013-9351
dc.identifier.urihttp://hdl.handle.net/10201/143011
dc.languageenges
dc.publisherElsevier
dc.relationThis work was supported by Fundación Séneca, Agencia y Tecnología de la Región de Murcia [08808/PI/08, 19443/PI/14]; Consejería de Innovación, Junta de Andalucía [P09-CTS-5488] and Ministerio de Economía, Industria y Competitividad, Instituto de Salud Carlos III (Acción Estratégica en Salud, AES) [PI10/00985, PI13/01237, PI13/02406].es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0013935121005831
dc.rightsinfo:eu-repo/semantics/embargoedAccesses
dc.subjectBisphenol A
dc.subjectEndocrine disruptor compounds
dc.subjectMale infertility
dc.subjectMale factor
dc.subjectSperm chromatin dispersion test
dc.subjectSperm DNA fragmentation
dc.titleAssociations between urinary concentrations of bisphenol A and sperm DNA fragmentation in young men.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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