Publication: What understanding tendon cell differentiation
can teach us about pathological tendon ossification
Authors
Magne, D. ; Bougault, C.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-11-614
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info:eu-repo/semantics/article
Description
Abstract
Tendons are the structures that attach
muscles to bones and transmit mechanical forces.
Tendon cells are composed of mature tenocytes and a
rare population of tendon stem cells. Both cell types
ensure homeostasis and repair of tendon extracellular
matrix to guarantee its specific mechanical properties.
Moreover, tendon cells seem to present a marked
potential for trans-differentiation, predominantly into the
chondrocyte and osteoblast lineages. In this review
article, we first present chronic tendon pathologies
associated with abnormal ossification, such as
spondyloarthritis and calcifying tendinopathy, and
discuss how tendon cell differentiation and transdifferentiation may participate in these diseases. We
moreover present the factors known to influence tendon
cell differentiation and trans-differentiation, with a
particular emphasis on extracellular environment,
mechanical stimulation and several soluble factors that
can tip the balance toward one or another lineage. A
better understanding of the neglected tendon cell biology
may be extremely useful to understand the pathological
mechanisms of spondyloarthritis and calcifying
tendinopathy.
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Citation
Histology and histopathology, Vol. 30, nº 8 (2015)
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