Publication: NF - KB function in the human myometrium during pregnancy and parturition
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Date
2010
Authors
Cookson, Victoria J. ; Chapman, Robert
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Interactions between the nuclear factor
kappaB (NF-κB) family of proteins (RelA, RelB, c-Rel,
p50 and p52) and DNA are vital for cells to function
normally; for example, in the human myometrium, NF-
κB-regulated pro-inflammatory mediators, including
TNFα, IL-1ß, IL-8 and COX-2 are associated with the
onset of labour. NF-κB, however, regulates the
expression of over 400 genes, although it is unlikely
these would all be activated in concert by a single
inducer. At present, defining the role of the NF-κB
RelA:p50 dimer, which governs a number of
inflammatory promoters, is at the forefront of the
parturition research field. However, to over-look the
function of other family members and how they may
regulate alternative signalling networks within
reproductive tissues, only serves to ensure we will never
fully understand the molecular circuitry influenced by
this family of transcription factors. Consequently this
review highlights other mechanisms by which the NF-
κB family of regulators have been shown to function in
other systems and how they may readily translate to
understanding the regulation underpinning human
parturition.
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