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The role of KMT2 gene in human tumors

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dc.contributor.authorZhang, Zhi Long
dc.contributor.authorYu, Peng Fei
dc.contributor.authorLing, Zhi Qiang
dc.date.accessioned2023-02-14T11:18:43Z
dc.date.available2023-02-14T11:18:43Z
dc.date.issued2022
dc.description.abstractHistone methylation plays a crucial role in the regulation of gene transcriptional expression, and aberration of methylation-modifying enzyme genes can lead to a variety of genetic diseases, including human cancers. The histone modified protein KMT2 (lysin methyltransferase) family are involved in cell proliferation, growth, development and differentiation through regulating gene expression, and are closely related with many blood cancers and solid tumors. In recent years, several studies have shown that mutations in the KMT2 gene occur frequently in a variety of human cancers and the mutation status of the KMT2 gene may be correlated with the occurrence, development and prognosis of some tumors. Research uncovering the clinical characteristics and molecular mechanisms of KMT2 mutation in human tumors will be helpful for early diagnosis and prognosis of tumors as well as drug development for targeted therapies.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.doihttps://doi.org/10.14670/HH-18-447
dc.identifier.eisbnHistology and Histopathology Vol. 37, nº4 (2022)es
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/128406
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectKMT2Aes
dc.subjectKMT2Ces
dc.subjectKMT2Des
dc.subjectGene mutationes
dc.subjectTumorigenesises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe role of KMT2 gene in human tumorses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.37, nº4 (2022)