Publication: Nitric oxide and nitric oxide synthase: biology, pathology, localization
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Date
1997
Authors
Wolf, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Nitric oxide (NO) has opened a new and
vigorous field of biological and clinical experimentation
as evidenced presently by about one hundred original
publications every week. Being a biological signal under
physiological conditions, NO may be «foe or friendn to
pathologically affected tissues. Major insights into the
biology and pathology of this unorthodox biomolecule
have come from the histochemical analysis of NO
synthase (NOS) and its molecular isoforms that are
responsible for the formation of NO. Immunocytochemistry
as well as NADPH-diaphorase histochemistry
are most widely used to visualize NOS in various
tissues. There are several constraints regarding
specificity and sensitivity of the techniques used and,
therefore, apparent discrepancies in the literature
concerning the cellular and subcellular distribution of
NOS and its isoforms. Despite such inconsistencies there
is a wealth of data that has an important impact on
further investigation of NO-mediated processes
underlying a vast number of NO-mediated physiological
and pathological mechanisms.
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