Publication: The role of TNFα/p53 pathway in endometrial cancer mouse model administered with apple seed extract
Authors
Kim, Sang Hwan
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-393
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info:eu-repo/semantics/article
Description
Abstract
y. Recent studies regarding the ability to relieve
and reconstitute the endometrium in the treatment of
endometrial cancer are limited. In this study, to analyze
endometrial cancer, early endometrial cancer was
induced by injecting a colon cancer cell line into the
lower abdominal cavity of mice. Subsequently, the apple
seed extract was administered orally to determine if the
extract could affect the endometrial cancer.
Administration of apple seed extract to the endometrial
cancer model confirmed that the apoptosis suppressing
mechanism was downregulated concurrently with the
reduced expression of NF-κB. In contrast, the TNFα/p53
pathway upregulated the apoptosis. A number of clinical
inferences could be derived from the results of this
study; moreover, the administration of apple seed extract
in a cancer metastasis model has not been reported in
earlier toxicity induction studies. The results of this
study indicated that the apple seed extract partially
enhances apoptosis and the immune function related
factors in endometrial cells. By improving tissue
remodeling, the extract may help to restore the
endometrium.
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