Liver fibrosis, the hepatic stellate cell
and tissue inhibitors of metalloproteinases

McCrudden, R.; Iredale, J. P.

Publication:
Liver fibrosis, the hepatic stellate cell and tissue inhibitors of metalloproteinases

dc.contributor.author	McCrudden, R.
dc.contributor.author	Iredale, J. P.
dc.date.accessioned	2020-09-01T10:14:04Z
dc.date.available	2020-09-01T10:14:04Z
dc.date.issued	2000
dc.description.abstract	Liver fibrosis occurs as a consequence of net accumulation of matrix proteins (especially collagen types I and III) in response to liver injury. The pathogenesis of liver fibrosis is underpinned by the activation of hepatic stellate cells (HSC) to a myofibroblast like phenotype with a consequent increase in their synthesis of matrix proteins such as interstitial collagens that characterise fibrosis. In addition to this there is increasing evidence that liver fibrosis is a dynamic pathologic process in which altered matrix degradation may also playa major role. Extracellular degradation of matrix proteins is regulated by matrix metalloproteinases (MMPS) - produced by HSC - which in turn are regulated by several mechanisms which include regulation at the level of the gene (transcription and proenzyme synthesis), cleavage of the proenzyme to an active form and specific inhibition of activated forms by tissue inhibitors of metalloproteinases (TIMPS). Insights gained into the molecular regulation of HSC activation will lead to therapeutic approaches in treatment of hepatic fibrosis in the future , and could lead to reduced morbidity and mortality in patients with chronic liver injury .	es
dc.format	application/pdf	es
dc.format.extent	10	es
dc.identifier.eisbn	Histology and Histopathology, Vol. 15, n.º 4 (2000)
dc.identifier.issn	0213-3911
dc.identifier.issn	1699-5848
dc.identifier.uri	http://hdl.handle.net/10201/95541
dc.language	eng	es
dc.publisher	F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Hepatic Stellate Cell (HSC)	es
dc.subject	Matrix Metalloproteinase (MMP)	es
dc.subject	Tissue Inhibitor of Metalloproteinase types 1 to 4 (TIMPs 1, 2, 3 & 4)	es
dc.subject	Liver fibrosis	es
dc.subject	Collagenase	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina	es
dc.title	Liver fibrosis, the hepatic stellate cell and tissue inhibitors of metalloproteinases	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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