Publication: Recent trends in the biotechnological production of tocopherols using in vitro cultures
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Date
2021-03-27
Authors
Almagro Romero, Lorena ; Belchí Navarro, Sarai ; Pedreño García, María Ángeles ; Sabater Jara, Ana Belén
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Publisher
Springer
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DOI
https://doi.org/10.1007/s11101-021-09742-8
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info:eu-repo/semantics/article
Description
© The Author(s), under exclusive licence to Springer Nature B.V. 2021. This document is the Published Manuscript version of a Published Work that appeared in final form in Phytochemistry Reviews. To access the final edited and published work see https://doi.org/10.1007/s11101-021-09742-8
Abstract
Tocopherols, a class of terpenoid compounds with vitamin-E activity, are produced by
photosynthetic organisms, including cyanobacteria,
algae, and plants. The chemical structure of tocopherols consists of a hydrophobic prenyl tail linked to
a polar chromanol head. Depending on the position
and number of methyl groups on the chromanol head,
tocopherols are classed as a, b, c, and d isomers.
Tocopherols play a key role in plant defense, and have
bioactive properties beneficial for human health, being
reported to prevent atherosclerosis, Parkinson’s and
Alzheimer’s diseases, eyesight degeneration, diabetes,
and coronary heart disease. The high market demand
for tocopherols calls for new strategies to improve
their supply from sustainable sources, and a promising
approach is to develop biotechnological factories with
tocopherol-producing plant and microalgae in vitro
cultures. This review provides a detailed overview of
different strategies devised to enhance tocopherol
production using such systems, with particular focus
on elicitation and feeding, culture conditions, and the
application of metabolic engineering.
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Citation
Phytochemistry Reviews, 2021, Vol. 20, pp. 1193–1207
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