Publication: Pathogenicity assessment of wild-type and mouse-adapted influenza A(H1N1)pdm09 viruses in comparison with highly pathogenic influenza A(H5N1) virus
Authors
Prokopyeva, E.A. ; Romanovskaya, A.A. ; Sharshov, K.A. ; Zaykovskaya, A.V. ; Alekseev, A. Yu. ; Shestopalov, A.M.
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-866
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info:eu-repo/semantics/article
Description
Abstract
Here we compare the results of pathological
and virological examinations of mice experimentally
infected with either wild-type or mouse-adapted
pandemic A(H1N1) pdm09 viruses and highly
pathogenic avian influenza (HPAI) virus A(H5N1). Mice
were sacrificed on days 1, 3, 6, and 10 post infection or
whenever morbidity was severe enough to justify
euthanasia. Morbidity rates were calculated on the basis
of clinical signs (weight loss, poor hair coat, hunched
posture and paresis); virus-induced disease was
characterised by the histopathology of lung; virus
dissemination was determined by virus isolation on
organ samples of lung, brain, liver, kidney and spleen.
All mice infected with mouse-adapted A(H1N1) pdm09
died in the course of the experiment, whereas 20% of
animals survived the infection with A(H5N1).
Echinocyte formation changed the rheological properties
of blood in animals infected with either mouse-adapted
A(H1N1) pdm09 or A(H5N1). To sum up, the adaptation
of pandemic A(H1N1) pdm09 virus can confer an
enhanced virulence similar to or even exceeding that of
HPAI A(H5N1) virus.
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Citation
Histology and Histopathology, Vol.32, nº10, (2017)
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