Publication: Role of chromatin disruption and histone acetylation in thyroid hormone receptor
action: implications in the regulation of HIV-1 LTR
Authors
Hsia, S.C.V. ; Tomita, A. ; Obata, Kazuya ; Paul, B. ; Buchholz, D. ; Shi, Y.B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Thyroid hormone (TH) affects a wide variety
of biological processes, from development to
physiological function of different cells and organs.
Alterations in plasma TH concentrations lead to
developmental abnormalities and pathological
consequences. Earlier studies have observed that plasma
TH levels vary in AIDS patients such that low levels of
TH correlate with survival rate. Furthermore, studies on
the regulation of the human immunodeficiency virus
type 1 (HIV-1) have shown that TH receptor (TR) is
capable of binding to two regions within the long
terminal repeat (LTR), which controls the transcription
of HIV-1 genome. The frog oocyte is an in vivo system
that allows microinjected DNA to be chromatinized in a
process mimicking the process that occurs in somatic
cells. Studies in the frog oocyte have provided in vivo
evidence on the role of chromatin remodeling in
transcriptional regulation by TR and have shown that TR
utilizes similar mechanisms in the regulation of the HIV-
1 LTR. That is, TR binds to LTR in chromatin in vivo
and represses the LTR in the absence of TH by recruiting
corepressor complexes containing histone deacetylases,
and upon TH binding, TR causes chromatin remodeling
and LTR activation.
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