Chitosan as stabilizing agent for negatively charged nanoparticles

Collado-González,  Mar; García Montalbán, Mercedes; Peña-García, Jorge; Pérez-Sánchez, Horacio; Víllora Cano, Gloria; Díaz Baños, F. Guillermo

Publication:
Chitosan as stabilizing agent for negatively charged nanoparticles

dc.contributor.author	Collado-González, Mar
dc.contributor.author	García Montalbán, Mercedes
dc.contributor.author	Peña-García, Jorge
dc.contributor.author	Pérez-Sánchez, Horacio
dc.contributor.author	Víllora Cano, Gloria
dc.contributor.author	Díaz Baños, F. Guillermo
dc.contributor.department	Biología Celular e Histología
dc.date.accessioned	2024-02-09T20:48:18Z
dc.date.available	2024-02-09T20:48:18Z
dc.date.copyright	© 2016 Elsevier Ltd. All rights reserved
dc.date.issued	2016-12-24
dc.description.abstract	Chitosan is a biocompatible polysaccharide with positive Z potential which can stabilize negative charged nanoparticles. Silk fibroin nanoparticles and citrate gold nanoparticles, both with negative Z potential, but they form aggregates at physiological ionic strength. In this work, we study the behavior of chitosan in solution when the ionic strength of the medium is increased and how the concentration of chitosan and the proportion of the two components (chitosan and AuNP or SFN) significantly affect the stability and size of the nanocomposites formed. In addition to experimental measurements, molecular modeling were used to gain insight into how chitosan interacts with silk fibroin monomers, and to identify the main energetic interactions involved in the process. The optimum values for obtaining the smallest and most homogeneous stable nanocomposites were obtained and two different ways of organization through which chitosan may exert its stabilizing effect were suggested.	es
dc.format	application/pdf	es
dc.format.extent	8	es
dc.identifier.citation	Carbohydrate Polymers 161 (2017) 63–70
dc.identifier.doi	http://doi.org/10.1016/j.carbpol.2016.12.043
dc.identifier.eissn	1879-1344
dc.identifier.issn	0144-8617
dc.identifier.uri	http://hdl.handle.net/10201/139155
dc.language	eng	es
dc.publisher	Elsevier	es
dc.relation	This work was partially supported by the European Commission (FEDER/ERDF) and the Spanish MINECO (Ref. CTQ2011-25613 and Ref. CTQ2014-57467-R), the Seneca Foundation of Science and Technology of Murcia (Projects 19499/PI/14 and 18946/JLI/13), the supercomputing infrastructure of the NLHPC (ECM-02) and the computing facilities of Extremadura Research Centre for Advanced Technologies (CETA CIEMAT). The authors also thank- fully acknowledge the computer resources and the technical support provided by the Plataforma Andaluza de Bioinformática of the University of Málaga. Mercedes G. Montalbán acknowledges support from Spanish MINECO (FPI grant, BES-2012-053267	es
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0144861716314175?via%3Dihub	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Chitosan	es
dc.subject	Gold nanoparticles
dc.subject	Silk ﬁbroin nanoparticles
dc.subject	Aggregation-Stabilizing effect
dc.subject	Dynamic light scattering
dc.subject	Molecular modeling
dc.title	Chitosan as stabilizing agent for negatively charged nanoparticles	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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