Publication: Involvement of lncRNA dysregulation in gastric cancer
Authors
Sun, Ming ; Nie, Feng-qi ; Wang, Zhao-xia ; De, Wei
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
10.14670/HH-11-655
item.page.type
info:eu-repo/semantics/article
Description
Abstract
y. Benefiting from the fast development of
sequencing technique and bioinformatics methods, more
and more new long non-coding RNAs (lncRNAs) are
discovered and identified. lncRNAs were firstly thought
to be transcription noise that from genome desert
without biological function; however, as the discovery of
lncRNA XIST and HOTAIR uncovers the emerging
roles of lncRNAs in development and tumorigenesis. In
the past decades, accumulating evidence have indicated
that lncRNAs involve in a wide range of biological
functions, such as X-chromosome inactivation,
reprogramming stem cell pluripotency, regulation of the
immune response and carcinogenesis. Although lots of
studies have demonstrated that dysregulation of
lncRNAs involve in diverse diseases including cancers,
the underlying molecular mechanisms of lncRNAs are
not well documented. Interestingly, our previous studies
and others’ have shown that numerous of lncRNAs
expression was misregulated in gastric cancer. In this
review, we will focus on the dysregulated lncRNAs and
their biological function and underlying pathways or
mechanisms in GC. Finally, we will discuss the potential
roles of lncRNAs acting as biomarkers or therapeutic
targets in GC patients.
publication.page.subject
Citation
Histology and Histopathology, vol.31, nº 1, (2016)
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/