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Cardiac Changes in Parkinson’s Disease: Lessons from Clinical and Experimental Evidence

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dc.contributor.authorCuenca Bermejo, Lorena
dc.contributor.authorAlmela, Pilar
dc.contributor.authorNavarro Zaragoza, Javier
dc.contributor.authorFernández Villalba, Emiliano
dc.contributor.authorGonzález Cuello, Ana María
dc.contributor.authorLaorden, María Luisa
dc.contributor.authorHerrero, María Trinidad
dc.contributor.departmentEnfermería
dc.date.accessioned2024-02-09T09:21:22Z
dc.date.available2024-02-09T09:21:22Z
dc.date.issued2021-12
dc.description©2021. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Published version of a Published Work that appeared in final form in International Journal of Molecular Sciences. To access the final edited and published work see https://doi.org/ 10.3390/ijms222413488
dc.description.abstractDysautonomia is a common non-motor symptom in Parkinson’s disease (PD). Most dysautonomic symptoms appear due to alterations in the peripheral nerves of the autonomic nervous system, including both the sympathetic and parasympathetic nervous systems. The degeneration of sympathetic nerve fibers and neurons leads to cardiovascular dysfunction, which is highly prevalent in PD patients. Cardiac alterations such as orthostatic hypotension, heart rate variability, modifications in cardiogram parameters and baroreflex dysfunction can appear in both the early and late stages of PD, worsening as the disease progresses. In PD patients it is generally found that parasympathetic activity is decreased, while sympathetic activity is increased. This situation gives rise to an imbalance of both tonicities which might, in turn, promote a higher risk of cardiac damage through tachycardia and vasoconstriction. Cardiovascular abnormalities can also appear as a side effect of PD treatment: L-DOPA can decrease blood pressure and aggravate orthostatic hypotension as a result of a negative inotropic effect on the heart. This unwanted side effect limits the therapeutic use of L-DOPA in geriatric patients with PD and can contribute to the number of hospital admissions. Therefore, it is essential to define the cardiac features related to PD for the monitorization of the heart condition in parkinsonian individuals. This information can allow the application of intervention strategies to improve the course of the disease and the proposition of new alternatives for its treatment to eliminate or reverse the motor and non-motor symptoms, especially in geriatric patients.es
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dc.format.extent20es
dc.identifier.citationInternational Journal of Molecular Sciences
dc.identifier.doihttps://doi.org/ 10.3390/ijms222413488
dc.identifier.issnPrint: 1661-6596
dc.identifier.issnElectronic: 1422-0067
dc.identifier.urihttp://hdl.handle.net/10201/139067
dc.languageenges
dc.publisherMDPIes
dc.relationThis work was supported by the Spanish Ministry of Science (SAF 2007-62262; SAF/FEDER 2013-49076-P; FIS PI1002827), the Seneca Foundation (FS/15329/PI/10 and 20847/PI/18) and personal funding from the Clinical and Experimental Neuroscience Group.es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectParkinson's diseasees
dc.subjectAginges
dc.subjectNeurodegenerationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiologíaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::614 - Higiene y salud pública. Contaminación. Prevención de accidentes. Enfermeríaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleCardiac Changes in Parkinson’s Disease: Lessons from Clinical and Experimental Evidencees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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