Publication:
Trace elements in saliva and plasma of patients with type 2 diabetes: Association to metabolic control and complications

Thumbnail Image
Files
diabetes.pdf(438.26 KB)
Date
2019-10-08
relationships.isAuthorOfPublication
relationships.isSecondaryAuthorOf
relationships.isDirectorOf
Authors
Marin Martinez, Luis ; Molino Pagan, Diana ; Lopez Jornet, Pia
item.page.secondaryauthor
item.page.director
Publisher
Elsevier Ltd.
publication.page.editor
publication.page.department
Dermatología, Estomatología, Radiología y Medicina Física
DOI
https://doi.org/10.1016/j.diabres.2019.107871
item.page.type
info:eu-repo/semantics/article
Description
© 2019. Elsevier Ltd. This document is the Published version of a published work that appeared in final form in Diabetes Research and Clinical Practice. To access the final edited and published work see https://doi.org/To access the final edited and published work see https://doi.org/10.1016/j.knosys.2021.107394
Abstract
Aim: An analysis is made of the saliva and plasma levels of trace elements in patients with type 2 diabetes mellitus and their association to metabolic control and the presence of chronic complications. Methods: A cross-sectional observational clinical study was carried out in 74 patients with type 2 diabetes mellitus. Mass spectrometry (ICP-MS) was used to determine the following trace elements in plasma and unstimulated basal saliva: 13Al, 16S, 4Be, 5B, 20Ca, 27Co, 29Cu, 24Cr, 38Sr, 15P, 3Li, 12Mg, 25Mn, 28Ni, 82Pb, 37Rb, 22Ti, 23V and 30Zn. Results: The levels of cobalt (p = 0.048) in saliva and of strontium (p = 0.001) in plasma were related to the presence of chronic complications. Significant differences with respect to metabolic control were observed for beryllium (p = 0.038), boron (p = 0.023) and phosphorus in saliva (p = 0.046), and for rubidium (p = 0.005), titanium (p = 0.016) and zinc in plasma (p = 0.013). A significant correlation (p < 0.001) was found between boron in plasma and boron in unstimulated basal saliva. Conclusions: The determination of trace elements in plasma and saliva constitutes a complementary tool for the assessment of metabolic control and for predicting chronic complications associated to type 2 diabetes mellitus. Further studies involving the biomonitoring of trace elements in saliva and plasma are needed
publication.page.subject
Trace elements , Saliva , Plasma , Type 2 diabetes mellitus
Citation
Diabetes Research and Clinical Practice Volume 157, November 2019, 107871
URI
http://hdl.handle.net/10201/137900
item.page.embargo
Collections
Artículos
Ir a Estadísticas