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Human trophoblast cell during first trimester after IVF-ET differs from natural conceived pregnancy in development and function

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dc.contributor.authorYang, Rui
dc.contributor.authorLiu, Ying Ying
dc.contributor.authorZhao, Liang
dc.contributor.authorWang, Ying
dc.contributor.authorLi, Rong
dc.contributor.authorLiu, Ping
dc.contributor.authorMa, Cai Hong
dc.contributor.authorChen, Xin Na
dc.contributor.authorQiao, Jie
dc.date.accessioned2022-02-15T09:29:12Z
dc.date.available2022-02-15T09:29:12Z
dc.date.issued2017
dc.description.abstractObjective. To explore the differences of the trophoblast cell function in first trimester between natural pregnancy and pregnancy after IVF-ET therapy. Methods. 102 cases with twin to singleton fetal reduction after IVF-ET treatment from July 2010 to August 2013 in Peking University Third Hospital were involved in analysis, and eight specimens were obtained from this group. 10 natural-pregnancy cases undergoing artificial abortion with unwanted pregnancy were recruited as control. Semi-quantitative immunohistochemical method was used to detect the expression of EGFR, Bcl-2, tubulin-α, metallothionein and AFP in villi in both groups. Results. Of the 102 cases, 14 cases (13.73%) were aborted. Preterm birth occurred in seven cases (7.86%). Low birth weight occurred in three patients (3.37%), and extremely low birth weight occurred in four cases (4.49%). The expression of EGFR, tubulin-α, Bcl-2, and metallothionein in the IVF-ET group was significantly lower than that in the control group (P<0.05). However, AFP expression was significantly higher in IVF-ET group than in control group (P<0.05). In IVF-ET group, the miscarriage case had weaker EGFR, tubulin-α, and metallothionein expression than full-term pregnancy; the early preterm labor case had weaker Bcl-2, tubulin-α, and metallothionein expression; and velamentous cord insertion case had weaker tubulin-α expression. Conclusions. The trophoblast cell function of IVF-ET group in first trimester is different from control group in proliferation, invasion, apoptosis and vascular development, and optimal pregnancy outcome depends on the self-healing balance of trophoblast cells.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.doiDOI: 10.14670/HH-11-787
dc.identifier.eisbnHistology and Histopathology, Vol.32, nº3, (2017)es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/117047
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCytotrophoblast celles
dc.subjectSyncytiotrophoblast celles
dc.subjectIn vitro fertilization and embryo transferes
dc.subjectNatural pregnancyes
dc.subjectProteomic analysises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleHuman trophoblast cell during first trimester after IVF-ET differs from natural conceived pregnancy in development and functiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.32, nº3 (2017)