Publication: HAVcR-1 involvement in cancer progression
Authors
Telford, Emily J.A. ; Jiang, Wen G. ; Martin, Tracey A.
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DoI: 10.14670/HH-11-817
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info:eu-repo/semantics/article
Description
Abstract
Formerly known for its importance in the
immune system and kidney regeneration, it is becoming
more apparent that HAVcR-1 is an important protein in
cancer biology. HAVcR-1 is overexpressed in numerous
cancers and associates with critical molecules of tight
junctions. Tight junctions are critical in homeostasis of
cellular compartments via the maintenance of epithelia
and endothelia however it has also be suggested that via
the prevention of dissemination, intravasation and
extravasation, tight junctions play a critical role in the
prevention of cancer metastasis. HAVcR-1 shedding and
the production of the HAVcR-1 ectodomain has been
linked to increased IL-6 thus implicated it in the process
of angiogenesis via the activation of the STAT3 pathway
leading to increased HIF-1α. The HAVcR-1 ectodomain
has also been shown to be a potential urinary biomarker
in certain cancers. HAVcR-1 is potentially important
molecule both for the detection of cancer and the
treatment of cancer by being a novel target for anticancer therapeutics.
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Citation
Histology and Histopathology, Vol.32, nº2, (2017)
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