Publication: Maternal urinary concentrations of bisphenol A during pregnancy are associated with global DNA methylation in cord blood of newborns in the “NELA” birth cohort
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Date
2022-06-03
Authors
Navarro Lafuente, Fuensanta ; Adoamnei, Evdochia ; Arense Gonzalo, Julián Jesús ; Prieto Sánchez, María Teresa ; Sánchez Ferrer, María Luisa ; Parrado, Antonio ; Fernández, Mariana F. ; Suarez, Beatriz ; López Acosta, Antonia ; Sánchez Guillamón, Antonio ; García-Marcos Álvarez, Luis Vicente ; Morales Bartolomé, Eva ; Mendiola Olivares, Jaime ; Torres Cantero, Alberto Manuel ; NELA Study group
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.scitotenv.2022.156540
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info:eu-repo/semantics/article
Description
Abstract
Endocrine disrupting chemicals (EDCs) set a public health risk through disruption of normal physiological processes. The toxicoepigenetic mechanisms of developmental exposure to common EDCs, such as bisphenol A (BPA), are poorly known. The present study aimed to evaluate associations between perinatal maternal urinary concentrations of BPA, bisphenol S (BPS) and bisphenol F (BPF) and LINE-1 (long interspersed nuclear elements) and Alu (short interspersed nuclear elements, SINEs) DNA methylation levels in newborns, as surrogate markers of global DNA methylation. Data come from 318 mother-child pairs of the `Nutrition in Early Life and Asthma´ (NELA) birth cohort. Urinary bisphenol concentration was measured by dispersive liquid–liquid microextraction and ultrahigh performance liquid chromatography with tandem mass spectrometry detection. DNA methylation was quantitatively assessed by bisulphite pyrosequencing on 3 LINEs and 5 SINEs. Unadjusted linear regression analyses showed that higher concentration of maternal urinary BPA in 24th week's pregnancy was associated with an increase in LINE-1 methylation in all newborns (p = 0.01) and, particularly, in male newborns (p = 0.03). These associations remained in full adjusted models [beta = 0.09 (95 % CI = 0.03; 0.14) for all newborns; and beta = 0.10 (95 % CI = 0.03; 0.17) for males], including a non-linear association for female newborns as well (p-trend = 0.003). No associations were found between maternal concentrations of bisphenol and Alu sequences. Our results suggest that exposure to environmental levels of BPA may be associated with a modest increase in LINE-1 methylation -as a relevant marker of epigenomic stability- during human fetal development. However, any effects on global DNA methylation are likely to be small, and of uncertain biological significance.
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Citation
Science of The Total Environment, 2022, Vol. 838, Part 4 : 156540
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