Publication: Impact of the complement cascade on posttraumatic cartilage inflammation and degradation
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Date
2007
Authors
John, T. ; Stahel, P.F. ; Morgan, S.J. ; Schulze-Tanzil, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The limited ability of articular cartilage to
recover from injury, remains an unsolved clinical
challenge in orthopaedic surgery. Persistent injury of the
articular surface can lead to the development of
posttraumatic osteoarthritis. The local inflammatory
response contributes to the pathogenesis of osteoarthritis
by inducing chondrocyte apoptosis and the de-regulation
of chondrocyte matrix remodelling. The role of the
complement system in contributing to secondary
inflammation-mediated cartilage degradation represents
a newer field of investigation. The purpose of this
review article is to summarize the known complementmediated
actions in cartilage homeostasis and injury.
This article focuses on the known effects of complement
on secondary chondrocyte apoptosis, and the interplay of
the complement system with pro-inflammatory
cytokines. Pharmacological therapies related to
complement inhibition will be discussed as they
potentially represent a new avenue for attenuating the
effect of the complement system on cartilage repair.
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