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A comprehensive morphometric analysis of the internal thoracic artery with emphasis on age, gender and left-to-right specific differences

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dc.contributor.authorLabudović Borović, Milica
dc.contributor.authorBorović, Saša
dc.contributor.authorMarinković-Erić, Jelena
dc.contributor.authorTodorović, Vera
dc.contributor.authorPuškaš, Nela
dc.contributor.authorKočica, Mladen
dc.contributor.authorRadak, Ðorde
dc.contributor.authorLačković, Vesna
dc.date.accessioned2018-09-05T14:53:36Z
dc.date.available2018-09-05T14:53:36Z
dc.date.issued2013
dc.description.abstractAims of the study. The aim of this analysis was the morphometric description of the internal thoracic artery (ITA) with an emphasis on age, gender and left-to-right specific differences, as well as on age and atherosclerosis related changes of the elastic skeleton. Methods. Forty eight arteries were obtained during forensic autopsies from 32 persons who had died of non-vascular causes. The following morphometric parameters were analyzed: thickness of the intima, the medial layer and the wall, the intima-to-media ratio and the elastic skeleton parameters. Results. The intima thickness increases significantly with aging (ANOVA F=34.061, p<0.001), as does the intima-to-media ratio (ANOVA F=10.831, p<0.001). With aging, there is a significant increase in the thickness of the media (F=56.519; p<0.001) and of the wall (F=34.094; p<0,001). There is a significant increase in the media thickness during the development of atherosclerosis in the ITA (ANOVA F=11.848, p<0.001). No significant difference was found when these data were analyzed based on the left-to-right principle or depending on gender of the patients. However, the analysis of the elastic skeleton parameters indicated that the combined effects of aging, atherosclerosis and male gender lead to the degeneration of the elastic skeleton of the ITA. Conclusion. The grade of atherosclerosis gradually increases with aging as shown by morphometric analysis. The increase in the medial layer thickness suggests the potential for positive remodeling of the ITA during aging and atherosclerosis. The left/right position has no influence on morphometric parameters of the ITA, while male gender affects parameters of the elastic skeleton.es
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dc.format.extent16es
dc.identifier.citationHistology and Histopathology, vol. 28, nº 10 (2013)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/60865
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectInternal thoracic arteryes
dc.subjectMorphometryes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.1 - Patología del sistema circulatorio, de los vasos sanguíneos. Transtornos cardiovasculareses
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleA comprehensive morphometric analysis of the internal thoracic artery with emphasis on age, gender and left-to-right specific differenceses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.28, nº10 (2013)