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Histological and stereological insights into renal and adrenal changes in pregnant rats exposed to wood smoke-derived PM2.5

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dc.contributor.authorSalinas, P.
dc.contributor.authorVillarroel, F.
dc.contributor.authorGonzález Torres, C.
dc.contributor.authorLazcano, T.
dc.contributor.authorSilva, J.
dc.contributor.authorMaulen, A.
dc.contributor.authorRojas, E.
dc.date.accessioned2025-05-07T15:20:21Z
dc.date.available2025-05-07T15:20:21Z
dc.date.issued2025
dc.description.abstractAir pollution, particularly fine particulate matter (PM2.5), is a global health issue affecting millions. In southern Chile, firewood used for heating exacerbates pollution, especially in winter. This study examines the impact of wood smoke-derived PM2.5 on kidney and adrenal gland morphology in pregnant rats. It evaluates chronic PM2.5 exposure effects during pregestational and gestational periods in Sprague-Dawley rats. Pregnant rats were exposed to PM2.5 in Temuco, a city with high wood smoke pollution. Filtered and unfiltered air chambers simulated different exposure conditions. Histological and stereological analyses were conducted on rat kidneys and adrenal glands using systematic sampling and STEPanizer software. Findings showed significant changes in renal and adrenal morphology due to PM2.5 exposure. In the kidney, variations were observed in glomerular compaction, proximal convoluted tubules, and medullary rays. In the adrenal gland, the zona fasciculata showed decreased acidophilia and lipid content, reduced cytoplasmic homogeneity, and the appearance of empty spaces. These effects were more pronounced in rats exposed to unfiltered air during both pregestational and gestational periods. Wood smoke-derived PM2.5 exposure significantly impacts kidney and adrenal morphology in pregnant rats, emphasizing the need for strategies to reduce environmental pollutant exposure during critical developmental periods to protect maternal-fetal health.es
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.doihttps://doi.org/10.14670/HH-18-863
dc.identifier.eisbnHistology and Histopathology Vol. 40, nº06 (2025)es
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/154082
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectKidneyes
dc.subjectHistologyes
dc.subjectStereologyes
dc.subjectWood smokees
dc.subjectPM2.5es
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleHistological and stereological insights into renal and adrenal changes in pregnant rats exposed to wood smoke-derived PM2.5es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.40, nº6 (2025)