Publication: Peripheral T-cell lymphoma or Hodg kin's disease in a HIV seropositive patient: a histopathological study
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Date
1989
Authors
Kanavaros, Panagiotis ; Nemeth, J. ; Lavergne, Anne ; Ngo Van, P. ; Galian, Annie
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Malignant lymphomas occurring in patients
with AIDS are usually derived from the B-cell lineage
while T-cell malignant lymphomas are very rare in these
patients.
We report a HIV seropositive 29-year-old homosexual
man in whom cervical lymph node biopsy showed an
atypical lymphoproliferative process. On morphological
and paraffin section immunohistochemical grounds
the possibility of Hodgkin's disease (HD) mixed cellularity
was initially suggested, but frozen section immunohistochemical
studies revealed that the cellular infiltrate
exhibited an aberrant pan T immunophenotype and consequently
the diagnosis of peripheral T-malignant lymphomas
(T-ML) was made. However, genotypic studies
would be required to definitely confirm this diagnosis, in
such cases.
In our case, varying numbers of small and mediumsized
cells were positive for both Leu 3lCD4 and Leu
2lCD8 whereas some large cells reacted only with
Leu 3lCD4 antibody. Some medium-sized, large and
giant cells showed cytoplasmic positivity for Leu
MlICD15. Furthermore, the positivity of many large and
giant cells with the activation markers BerH2lCD30,
Ki-1lCD30, TacICD25 and HLA-DR suggested an activation
state for these cells. Our findings emphasize the usefulness of frozen section immunohistochemical methods
in order to investigate the spectrum of lymphoid
malignancies occurring in HIV seropositive patients, and
confirm results of previous studies which stressed the
diagnostic difficulties that may appear in distiguishing
HD from peripheral T-ML.
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