Publication: Antinuclear antibody-keratinocyte interactions in photosensitive cutaneous lupus erythematosus
Loading...
Date
1999
Authors
Furukawa, F.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Autoimmune diseases are characterized by
various circulating autoantibodies, especially antinuclear
antibodies (ANA). It has been a long-standing issue as to
whether andlor how ANA interact with epidermal cells
to produce skin lesions. Of these ANA, the anti-SS-AIR0
antibody is the most closely associated with photosensitivity
in patients with systemic lupus erythematosus
(SLE) and its subgroups, including subacute cutaneous
lupus erythematosus (SCLE) and neonatal lupus
erythematosus (NLE). SS-A/Ro antigens are present in
the nucleus and cytoplasm, and interestingly, ultraviolet
B (UVB) light translocates these antigens to the surface
of the cultured keratinocytes. Thus, anti-SS-AIR0
antibodies in the sera can bind to the relevant antigens
expressed on the UVB-irradiated keratinocyte surface,
and have been speculated to be an important inducer of
antibody-dependent keratinocyte damage. This interaction
between the anti-SS-A/Ro antibodies and UVBirradiated
keratinocytes may induce the skin lesions
through a cytotoxic mechanism. This review will focus
on the involvement of antibody-dependent cellular cytotoxicity
in the pathogenesis of the skin lesions observed
in photosensitive cutaneous lupus erythernatosus.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.