Publication:
Lectin histochemical study on the kidney of normal and streptozotocin-induced diabetic hamsters

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Authors
Aguirre, J.I. ; Han, J.S. ; Itagaki, S. ; Doi, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Lectin histochernical characteristics of the kidney of normal and streptozotocin (SZ)-induced diabetic APA harnsters were investigated. Paraffin sections of the kidney of animals killed at 1 and 3 rnonths after SZ-injection were stained with the following 10 lectins: PNA, BPA, DBA, SBA, GSA-1, GSA-11, MPA, WGA, UEA-1 and Con A. Renal lectin binding characteristics of normal APA harnsters differed in sorne aspects from those in other species reported previously. In the kidney of SZ-induced diabetic APA hamsters, binding activities of sorne lectins increased in the affected Bowman's capsules and glorneruli as well as in degenerated epithelial cells of uriniferous tubules. Among thern, GSA-11 in particular exhibited strong binding activity to the degenerated epithelial cells of Bowman's capsules, dista1 convoluted tubules and collecting ducts.
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Citation
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