Publication: Small molecule GSK-3 antagonists play a pivotal role in reducing the local inflammatory response, in promoting resident stem cell activation and in improving tissue repairing in regenerative dentistry
Authors
Tatullo, Marco ; Makeeva, Irina ; Rengo, Sandro ; Rengo, Carlo ; Spagnuolo, Gianrico ; Codispoti, Bruna
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-133
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info:eu-repo/semantics/article
Description
Abstract
Regenerative dentistry is attracting growing
interest in the scientific community, mainly because of
its translational and promising therapeutic approach.
The latest research carried out by the scientific
community are aimed at triggering the local cellular
response, in order to induce a physiological self-
repairing of damaged oral tissues. Such physiological
processes mainly involve the activation of local stem cell
populations: mesenchymal stem cells, in fact, retain the
ability to proliferate and to differentiate towards
functional mature elements, thus leading towards healing
of damaged tissues.
Glycogen Synthase Kinase-3 (GSK-3) is a key-
regulator of the Wnt/β-catenin pathway; it
phosphorylates β-catenin, that then is degraded in the
cytosol. The activation of such signalling, mediated by
Wnt ligand/receptor association, inhibits GSK-3, leading
to translocation of β-catenin to the nucleus and to gene
transcription. Selective inhibitors of GSK-3 have been
linked to the activity of Wnt signalling and to the
regeneration of injured tissues, including complex dental
and oral structures.
Small Molecule GSK-3 Antagonists are the most
interesting class of molecules acting with a "Bystander
effect": reducing local inflammation and local bone
resorption and triggering the activity and differentiation
of resident "sleeping" MSCs. The aim of this narrative
topical review is to describe the current knowledge on
the role of small molecule GSK-3 antagonists in
regenerative dentistry, with strategic insights towards the
translational applications in nanomaterials in dentistry
and in dental repairing.
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Citation
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