Publication: Characterization of the glycoconjugate sugar residues in developing chick esophageal epithelium
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Date
1993
Authors
Gheri, G. ; Gheri Bryk, S. ; Sgambati, E. ; Gulisano, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The development of the esophagus in the
chick embryo is characterized by remarkable
morphological changes especially at the level of the
epithelium. Using horseradish peroxidase-conjugated
lectins (DBA, PNA, SBA, WGA, ConA, LTA, UEAI)
we have studied, at the level of the esophagus of chick
embryos from the 8th to the 21st day of incubation and
of 1- and 2-day-old chicken, the evolution of the
saccharidic moieties of glycoconjugates, which precedes
andlor is concomitant with the epithelial morphological
transformations. We have found differences in content
and cellular distribution of oligosaccharides during the
histogenetic processes which characterize the lining and
glandular epithelium. Before the appearance of cilia and
mucus secretion at the bathyprismatic epithelial cells, the
sugar residues D-galactose-(B 133)-N-acetyl-Dgalactosamine,
B-N-acetyl-D-galactosamine and a-Lfucose
were detected only at the luminal cell surface.
These oligosaccharides were probably involved in giving
rise to the polarization of the esophageal epithelial cells.
The esophageal gland mucus was first characterized by
the presence of a-L-fucose and afterwards also by
the presence of D-galactose-(Bl33)-N-acetyl-Dgalactosamine,
D-glucosamine and sialic acid.
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