Publication: Linkage between cell membrane proteins and actin-based cytoskeleton the cytoskeletal-driven cellular functions
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Date
2000
Authors
Fais, S. ; Luciani, F. ; Logoui, M. ; Parlato, S. ; Lozupone, F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Asymmetric organization of the plasma
membrane and cytosolic organelles is fundamental for a
variety of cells, including bacteria, yeast and eukaryotic
cells (Nelson, 1992). The degree into which cells
polarize is characterized by their ability to create and
maintain morphologically and biochemically distinct
plasma membrane domains. The generation and
maintenance of polarized distribution of membrane
components (proteins and lipids) is thus critical to the
ability of cells to perform complex activities such as
cell-to-cell interactions, vectorial transport and secretion,
cellular immunity, development and morphogenesis.
Modification of cellular polarity may potentially lead to
abnormal cellular activities and various pathological
disorders (Molitoris, 1991; Carone et al., 1994; Chen et
al., 1995). Our review shows the complex interplay
between membrane proteins and the cytoskeletal
network in determining the "polarized phenotype" in the
cell. We provide evidence that membrane/cytoskeleton
interaction is the key to regulation of the vast majority of
cellular functions.
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