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Sustainable synthesis of branched-chain diesters

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dc.contributor.authorSerrano-Arnaldos, M.
dc.contributor.authorOrtega Requena, Salvadora
dc.contributor.authorSánchez, J.A.
dc.contributor.authorHernández, A.
dc.contributor.authorMontiel, M.C.
dc.contributor.authorMáximo, F.
dc.contributor.authorBastida, J.
dc.contributor.departmentIngeniería Química
dc.date.accessioned2024-01-31T10:07:05Z
dc.date.available2024-01-31T10:07:05Z
dc.date.issued2020-11-11
dc.description©<2021>. This manuscript version is made available under the CC-BY-NC-ND license http://creativecommons.org/licenses/ccby-nc-nd/4.0/ This document is the Published, version of a Published Work that appeared in final form in [Journal of Biotechnology]. To access the final edited and published work see [https://doi.org/10.1016/j.jbiotec.2020.11.013]
dc.description.abstractEsters from branched alcohols and dicarboxylic linear acids are widely used as lube bases due to their good performance at low temperatures. This work proposes a new process to synthesize bis(2-ethylbutyl) adipate and bis(2-ethylbutyl) sebacate by using the lipase-based catalyst Novozym® 435 in a solvent-free system. Different reaction strategies have been tested in order to minimize 2-ethyl-1-butanol losses due to its evaporation and optimum operation conditions have been determined: 2.5 % of biocatalyst, 50 °C and a molar excess of alcohol of 15 % for the adipic diester and of 25 % for the sebacic one. It has also been proven that the immobilized enzyme can be reused in seven successive reaction cycles, achieving high yields without an appreciable reduction of activity. This biocatalytic pathway is a promising basis for the development of a more sustainable large scale process for obtaining biodegradable lubricants, as it is pointed out by productivity, economic and green metrics calculations.es
dc.formatapplication/pdfes
dc.format.extent31es
dc.identifier.citationJournal of Biotechnology. Volume 325, Pages 91 - 99, 2021
dc.identifier.doihttps://doi.org/10.1016/j.jbiotec.2020.11.013
dc.identifier.issnPrint: 0168-1656
dc.identifier.urihttp://hdl.handle.net/10201/138279
dc.languageenges
dc.publisherElsevier
dc.relationOrganismo financiador: MINISTERIO DE CIENCIA, INNOVACIÓN Y UNIVERSIDADES. Convocatoria: 2018 DE PROYECTOS DE I+D+i «RETOS INVESTIGACIÓN». Proyecto: PROCESOS SOSTENIBLES PARA LA SINTESIS BIOCATALITICA DE ESTERES RAMIFICADOS. Código: RTI2018-094908-B-I00es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S016816562030314X?via%3Dihubes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBiolubricantses
dc.subjectBis(2-ethylbutyl) adipatees
dc.subjectBis(2-ethylbutyl) sebacatees
dc.subjectLipasees
dc.subjectSolvent-freees
dc.subject.otherCDU::5 - Ciencias puras y naturales::54 - Química
dc.titleSustainable synthesis of branched-chain diesterses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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