Publication: Prognostic analysis of astrocytic gliomas correlating histological parameters with the proliferating cell nuclear antigen labelling index (PCNA-LI)
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Date
1997
Authors
Cruz-Sánchez, F. F. ; Ferreres, Joan-Carles ; Figols, J. ; Palacín, A. ; Cardesa, Antonio ; Rossi, M.L. ; Val-Bernal, José Fernando
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Eighty out of 250 cases of astrocytic glioma
collected from a practice served by a single clinical team
over a 15-year period were studied using a full
complement of clinical, follow up, histopathological
analysis and proliferating cell nuclear antigen (PCNA)
immunostaining for the obtention of the PCNA-labelling
index (LI). A statistical evaluation and discriminant
analysis were carried out with the aim of clarifying the
importance of various parameters as predictors of tumor
behaviour. Data are correlated with survival (with a 10-
year follow up).
A significant correlation with survival was found
when histological grouping and the PCNA-LI were
studied with the Cox test. Most significant features were
histological as detected using classical techniques
including histological grading. The utilization of
objective values (mitosis, cellular density and necrosis)
appears to be useful in grading astrocytic tumors. Our
results emphasize the importance of cytological,
histological and PCNA-LI parameters as predictors of
tumor behaviour.
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