Publication: Proteinase-antiproteinase imbalance in the pathogenesis of Emphysema: The role of metalloproteinases in lung damage
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Date
1999
Authors
Pardo, A. ; Selman, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Pulmonary emphysema refers to a lung
disorder characterized by a diffuse destruction of the
alveolar walls resulting in enlargement of the distal
airspaces. The disease is usually a chronic, progressive,
and disabling disorder. The concept of proteinaselantiproteinase
imbalance evolved from the identification of
patients with al-antytripsin deficiency, and from the
development of experimental emphysematous lesions
using different enzymes. For a long time, this concept
was seen as an elastase/antielastase imbalance, with the
consequent degradation of elastin. Recent evidence,
however, suggests that an intricate process of pulmonary
remodeling occurs during the development of emphysema,
where a complex network of serine proteases and
metalloproteinases capable of degrading different
extracellular matrix molecules, primarily, but not
exclusively fibrillar collagens and elastin, are implicated
in the pathogenesis of this disease.
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