Publication: Biocatalytic synthesis of panthenyl monoacyl esters in ionic liquids and deep eutectic solvents
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Date
2019-05-21
Authors
Lozano Rodríguez, Pedro ; Álvarez, Elena ; Nieto Cerón, Susana ; Villa Aroca, Rocío ; Bernal, Juana M. ; Donaire González, Antonio
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Publisher
Royal Society of Chemistry
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DOI
https://doi.org/10.1039/C9GC01076A
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info:eu-repo/semantics/article
Description
© The Royal Society of Chemistry 2013. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Green Chemistry. To access the final edited and published work see https://doi.org/10.1039/C9GC01076A
Abstract
The enzymatic synthesis of six panthenyl monoacyl esters (PMEs) was carried out by the direct esterification of fatty acids (i.e. capric, lauric, myristic, palmitic, oleic and linoleic acids, respectively) with panthenol in different ionic liquids (ILs) based on cations with a long alkyl side-chain (e.g. 1-dodecyl-3-methylimidazolium tetrafluoroborate [C12mim][BF4], etc.). All the assayed ILs were seen to be suitable reaction media for Novozym 435-catalyzed synthesis of PMEs (i.e. up to 90% conversion and 100% selectivity), enabling easy recovery and the reuse of both biocatalyst and IL. Alternatively, mixtures of panthenol with free fatty acids were seen to act as deep eutectic solvents (DES), that were excellent reaction media for the biocatalytic synthesis of PMEs (i.e. up to 83% conversion and 98% selectivity in the case of the panthenyl monolaurate), the enzymatic activity remaining unchanged for seven consecutive cycles of reuse. The enzymatic synthesis of PMEs by direct esterification using the DES approach can be considered as a clean and useful process for the sustainable industrial scaling up of panthenyl acyl ester production.
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Citation
Green Chemistry, 2019, Vol. 21, Issue 12, pp. 3353-3361
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1-ene-2999
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