Publication: Regulated expression of MCP-I by osteoblastic cells in vitro and in vivo
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Date
1999
Authors
Graves, D.T. ; Jiang, Y. ; Valente, A.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Inflammation is characterized by the
recruitment of leukocytes from the vasculature. Recent
studies have implicated chemokines as an important
class of mediators that function principally to stimulate
leukocyte recruitment, and in some cases, leukocyte
activity. There are four defined chemokine subfamilies
based on their primary structure, CXC, CC, C and
CX3C. Members of the CC chemokine subfamily, such
as monocyte chemoattractant protein 1 (MCP-l), are
chemotactic for monocytes and other leukocyte subsets.
The studies described below focus on the expression of
MCP-1 in vitro and in vivo in an osseous environment.
These studies indicate that MCP-1 is typically not
expressed in normal bone or by normal osteoblasts in
vitro. Upon stimulation by inflammatory mediators,
MCP-1 is up-regulated. This expression is temporally
and spatially associated with the recruitment of
monocytes in both osseous inflammation and during
developmentally regulated bone remodelling. Furthermore,
exogenous MCP-1 applied to inflamed bone
enhances the recruitment of monocytes. Because
monocytes produce factors that influence osseous
metabolism, including but not limited to prostglandins,
platelet-derived growth factor, interleukin-l or tumor
necrosis factor, chemokines that initiate their recruitment
are likely to be highly important.
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