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Nitric oxide, prostaglandins and angiotensin II in the regulation of renal medullary blood flow during volume expansion

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dc.contributor.authorMoreno, Coral
dc.contributor.authorLlinás Más, María Teresa
dc.contributor.authorRodríguez, Francisca
dc.contributor.authorMoreno, Juan M.
dc.contributor.authorSalazar, Francisco Javier
dc.contributor.departmentFisiología
dc.date.accessioned2025-03-17T13:01:24Z
dc.date.available2025-03-17T13:01:24Z
dc.date.issued2015-11-26
dc.description© University of Navarra 2015. This document is the Published version of a Published Work that appeared in final form in Journal of Physiology and Biochemistry. To access the final edited and published work see https://doi.org/10.1007/s13105-015-0450-8
dc.description.abstractRegulation of medullary blood flow (MBF) is essential in maintaining renal function and blood pressure. However, it is unknown whether outer MBF (OMBF) and papillary blood flow (PBF) are regulated independently when extracellular volume (ECV) is enhanced. The aim of this study was to determine whether OMBF and PBF are differently regulated and whether there is an interaction between nitric oxide (NO), prostaglandins (PGs) and angiotensin II (Ang II) in regulating OMBF and PBF when ECV is enhanced. To achieve these goals, OMBF and PBF were measured by laser-Doppler in volume-expanded rats treated with a cyclooxygenase inhibitor (meclofenamate, 3 mg/kg) and/or a NO synthesis inhibitor (L-nitro-arginine methyl ester (L-NAME), 3 μg/kg/min) and/or Ang II (10 ng/kg/min). OMBF was unchanged by NO or PGs synthesis inhibition but decreased by 36 % (P < 0.05) when L-NAME and meclofenamate were infused simultaneously. PBF was similarly reduced by L-NAME (12 %), meclofenamate (17 %) or L-NAME + meclofenamate (19 %). Ang II did not modify OMBF, but it led to a similar decrease (P < 0.05) in OMBF when it was administered to rats with reduced NO (32 %), PGs (36 %) or NO and PGs (37 %) synthesis. In contrast, the fall in PBF induced by Ang II (12 %) was enhanced (P < 0.05) by the simultaneous PGs (30 %) or PGs and NO (31 %) synthesis inhibition but not in L-NAME-treated rats (20 %). This study presents novel findings suggesting that blood flows to the outer medulla and renal papilla are differently regulated and showing that there is a complex interaction between NO, PGs and Ang II in regulating OMBF and PBF when ECV is enhanced.es
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dc.format.extent8
dc.identifier.citationJournal of physiology and biochemistry, 72, 1-8
dc.identifier.doihttps://doi.org/10.1007/s13105-015-0450-8
dc.identifier.issnPrint: 1138-7548
dc.identifier.issnElectronic: 1877-8755
dc.identifier.urihttp://hdl.handle.net/10201/151802
dc.languageenges
dc.publisherSpringer
dc.relationThis study was supported by a grant from the Dirección General de Investigación Científica y Técnica of Ministerio de Economía y Competitividad (BFU2013-49098R).es
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s13105-015-0450-8
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectRenal medulaes
dc.subjectAngiotensin II
dc.subjectL-NAME
dc.subjectMeclofenamate
dc.subjectVolume expansion
dc.subjectLaser-Doppler
dc.titleNitric oxide, prostaglandins and angiotensin II in the regulation of renal medullary blood flow during volume expansiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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