Publication: Chaperone-mediated autophagy in
cancer: Advances from bench to bedside
Authors
Hou, Tao ; Fan, Yizeng ; Dan, Weichao ; Liu, Bo ; Wang, Zixi ; Zeng, Jin ; Li, Lei
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-202
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info:eu-repo/semantics/article
Description
Abstract
Chaperone-mediated autophagy (CMA), a
selective form of autophagy, where cellular proteins with
KFERQ-like motif are targeted to the lysosome for
degradation, is necessary to maintain cellular
homeostasis. The role of CMA in neurodegenerative
diseases has been extensively studied in the past
decades, with defects in the pathway being strongly
associated with disease. Recently, accumulating
evidence has demonstrated a consistent increase in basal
CMA activity in a wide array of cancer cell lines and
human tumor biopsies, suggesting a potential link
between CMA and cancer. On the other hand, an anti-
oncogenic role for CMA under physiological conditions
in non-transformed cells is also proposed despite the
pro-tumorigenic function of CMA in cancer cells. The
growing number of connections between CMA and
cancers has generated interest in modulating CMA
activity for therapeutic purposes. Here, we describe
recent advances in the understanding of the molecular
regulation of CMA, and discuss the evidence in support
of the contribution of CMA dysfunction to cancers
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Citation
Histology and Histopathology Vol. 35, nĀŗ7 (2020)
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