Publication: Betalain health-promoting effects after ingestion in Caenorhabditis elegans are mediated by DAF-16/FOXO and SKN-1/Nrf2 transcription factors
Authors
Guerrero Rubio, M. Alejandra ; Jiménez Atiénzar, Mercedes ; Cabanes Cos, Juana ; Escribano Cebrián, Josefa ; Gandía Herrero, Fernando ; García Carmona, Francisco ; Hernández García, Samanta
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.foodchem.2020.127228
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info:eu-repo/semantics/article
Description
Abstract
Betalain-rich extracts have been used for many years by their nutraceutical potential. However, the study of their
bioactivities has always been hampered by their difficult obtention. To explain their mode of action, seventeen
pure betalains were tested in vivo using the animal model C. elegans. Four betalains, named indicaxanthin,
indoline carboxylic acid-betacyanin, phenylalanine-betaxanthin, and dopaxanthin, behaved as extraordinary in
vivo antioxidants and anti-aging compounds, by increasing the lifespan of C. elegans up to 16.82%, 16.65%,
16.53%, and 12.93%, respectively. The first microarrays performed with betalains and biological confirmation
with different mutant strains showed that this life extension is due to a reduction of oxidative stress and the
activation of the transcription factors DAF-16/FOXO and SKN-1/Nrf2. They are involved in longevity and oxidative stress resistance pathways and lead to overexpression of HSPs genes, involved in resistance to cancer and Alzheimer's, opening novel research lines in the search for effective plant-based treatments.
Citation
Food Chemistry, 2020, Vol. 330 : 127228
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