Publication: Endothelial heat shock response in cerebral ischemia
Authors
Scumpia, A.J. ; Kafel, J. ; Hallas, B.H. ; Horowitz, J.M. ; Torres, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Blood vessels and nerve fibers often course
alongside one another in an orderly fashion throughout
the brain. This clustering gives rise to a reciprocal
signaling network between endothelial and nerve cells
that follows highly stereotyped anatomical patterns. One
such molecular signal that is produced by endothelial
cells and acts on surrounding neurons is heat shock
protein 70. Here we briefly review recent studies that
have revealed a critical role of this signaling pathway
during harmful insults to the brain, particularly during
episodes of cerebral ischemia.
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Citation
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