Publication: Molecules of cell adhesion and extracellular matrix proteolysis in oral squamous cell carcinoma
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Date
2010
Authors
Shi, Zonggao ; Stack, M. Sharon
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Oral squamous cell carcinoma (OSCC) is
the most common malignancy of the oral cavity with a
poor 5-year survival rate, due in large part to the
presence of metastatic disease at initial diagnosis. In
recent years, a number of studies have examined the oral
tumor microenvironment to asses the potential dynamic
balance between extracellular matrix deposition and
proteolytic degradation as well as the cellular adhesion
molecules that mediate adhesion to matrix and regulate
tissue cohesion. The objective of this review is to
provide a brief overview of the major matrix
components, adhesion molecules and proteolytic
enzymes in the oral tumor microenvironment and to
summarize recent findings regarding the role of these
complex molecular players in oral tumor progression.
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