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Haemangioblastoma, Histological and immunohistological study of an enigmatic cerebellar tumour

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dc.contributor.authorCruz-Sánchez, F. F.es
dc.contributor.authorRossi, M.L.es
dc.contributor.authorRodríguez-Prados, S.
dc.contributor.authorNakamura, N.
dc.contributor.authorHughes, J.T.
dc.contributor.authorCoakham, H.B.
dc.date.accessioned2011-02-01T08:45:04Z
dc.date.available2011-02-01T08:45:04Z
dc.date.issued1990
dc.description.abstractParaffin-embedded blocks of 36 cerebellar haemangioblastomas were reacted with a panel of antibodies including glial fibrillary acidic protein, vimentin, epithelial membrane antigen, cytokeratin, Factor VIII, a neuroendocrine marker and with Ulex europaeus. agglutinin The main histological features, apart from the characteristic large abnormal vessels, were a prominent reticulin network, a cystic architecture and cellular and nuclear polymorphism. Two cell types were identified: endothelial and stromal. Twenty tumours were positive for glial fibrillary acidic protein because of included or reactive astrocytes as well as positive stromal cells. Vimentin was positive in all tumours with a diffuse distribution and a somatic pattern; blood vessels, stromal cells and reactive astrocytes were strongly positive. Factor V111 and Ulex europaeus agglutinin reactivity were present in a similar pattern of staining in endothelium and in five cases there were stromal cells that were positive with the latter. We were not able to ascertain the histogenesis of the stromal cell, which remains enigmatic.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18190
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCerebellumes
dc.subjectHaemangioblastomaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleHaemangioblastoma, Histological and immunohistological study of an enigmatic cerebellar tumoures
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 5, nº 4 (1990)