Publication: Broccoli byproduct extracts attenuate the expression of UVB-induced proinflammatory cytokines in HaCaT keratinocytes
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Date
2024-12-02
Authors
Borja Martínez, María ; Pedreño, María Angeles ; Sabater Jara, Ana Belén
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Publisher
MDPI
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DOI
https://doi.org/10.3390/ antiox13121479
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info:eu-repo/semantics/article
Description
© 2024 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in Antioxidants. To access the final edited and published work see https://doi.org/10.3390/antiox13121479
Abstract
Broccoli byproducts are an important source of bioactive compounds, which provide important benefits for human skin due mainly to their antioxidant and anti-inflammatory properties. The
primary target of UVB radiation is the basal layer of cells in the epidermis, with keratinocytes being
the most abundant cell population in this layer. Given the wide range of side effects caused by exposure to UVB radiation, reducing the amount of UV light that penetrates the skin and strengthening the
protective mechanisms of the skin are interesting strategies for the prevention of skin disorders. This
work aims to evaluate the protective mechanisms triggered by broccoli by-products extract (BBE) on
HaCaT keratinocytes exposed to UVB radiation as well as the study of the regenerative effect of these
extracts on the barrier of skin keratinocytes damaged by superficial wounds as a strategy to revalorize
this agricultural waste. The results obtained revealed that the BBEs exhibited a high cytoprotective
effect on the HaCaT exposed to UVB light, allowing it to effectively reduce the intracellular content of
ROS, as well as effectively attenuating the increase in proinflammatory cytokines (IL-1β, IL-6, IL-78,
TNF-α) and COX-2 induced by this type of radiation. Furthermore, the BBE could be an excellent
regenerative agent for skin wound repair, accelerating the migration capacity of keratinocytes thus
contributing to the valorization of this byproduct as a valuable ingredient in cosmetic formulations.
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Citation
Antioxidants, 2024, Vol. 13 (12) : 1479
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