Publication: Function of inflammatory cells and neoral cyclosporin-A
in heart transplant-associated coronary vasculopathy
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Date
2001
Authors
Buján, J. ; Jurado, F. ; Gimeno, M. J. ; Rodriguez, M. ; Bellón, J. M.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The role of Sandimmun Neoral® (S-n) and
the immune response in transplant-associated coronary
vasculopathy (TACV) was evaluated in a Lewis (Lew)-
to-Fischer-344 (F344) rat abdominal heterotopic heart
transplant model. Some of the transplant recipients were
treated with S-n (5mg/ kg/ day) for 14 days posttransplant, or until sacrifice. Grafts were subjected to
immunohistochemical (ED1, CD4, CD8 and a-actin+
cells) anal ysis from day 7 to 100 post-transplant.
Singenic controls did not develop TACV, irrespective of
whether they had received the drug or not. TACV was
detected in Lew-F344 transplants regardless of S-n
administration with participation of ED1+, CD8+ and aactin+ cells, although its incidence was lower in animals
receiving prolonged S-n treatment. In this model,
accelerated arteriosclerosis of the graft appeared to be
related more to the rejection effect than to the action of
the immunosuppressive agent.
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Citation
Histology and Histopathology, Vol. 16, n.º 1 (2001)
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