Publication: Expression of renin in coagulating glands
Authors
Kon, Yasuhiro ; Endoh, Daiji
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The presence of an extrarenal or local reninangiotensin
system has been noted in several tissues,
although their functions have not yet been clarified.
Renin from the coagulating gland (CG), is the most
recently discovered local renin, and is a significant
subject for investigation with histological and molecular
biological techniques. Dot-like reactions for renin are
detected immunohistochemically in the epithelial cells of
CGs of the strains C57BL16 mice. Excretory products of
some terminal lumina are also found to be positive for
renin. Colloidal gold particles, indicating the presence of
renin, are detected in the lysosomal granules, in which
they are especially located on the crystalline structure.
They are also observed in the production of series of
exocrine granules. At the apical region, both reninpositive
exocrine and lysosomal granules are secreted by
exocytosis. In the development, immunoreactivity for
renin is first detected at 6 weeks after birth. After that
time, the number of renin-containing cells gradually
increase throughout the development. In adults, severa1
pattems of renin immunoreactivity are demonstrated in
almost al1 epithelial cells of CGs. At 4 weeks after
castration, renin-containing cells in terminal ducts are
decreased and remain at very low levels. After
testosterone injection, the numerical value of renincontainingis detected in the CGs by Northern blot analysis and
hybridohistochemistry. These findings suggest that renin
is synthesized depending on testosterone, and released
by exocrine secretion.
cells is high at 1 week. Finally, renin mRNA
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