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CK20 and lymph node involvement predict adverse outcome of malignant intraductal papillary neoplasm of the bile duct

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dc.contributor.authorShi, Jie
dc.contributor.authorWan, Xueshuai
dc.contributor.authorXie, Yuan
dc.contributor.authorLin, Jianzhen
dc.contributor.authorLong, Junyu
dc.contributor.authorXu, Weiyu
dc.contributor.authorLiang, Zhiyong
dc.contributor.authorSang, Xinting
dc.contributor.authorZhao, Haitao
dc.date.accessioned2022-11-17T10:09:36Z
dc.date.available2022-11-17T10:09:36Z
dc.date.issued2020
dc.description.abstractObjectives. To identify prognostic factors of malignant intraductal papillary neoplasm of the bile duct (m-IPNB). Materials and Methods. We included 38 consecutive cases which underwent surgical resection and diagnosed as IPNB with malignant component from January 2003 to January 2017. Clinicopathological variables were collected to conduct survival analysis and identify prognostic factors. Results. The median overall survival (OS) of m- IPNB was 76.0 months, with 1-, 3-, and 5-year survival rates of 97.2%, 73.5%, and 59.8%, respectively. The median recurrence-free survival (RFS) was 48.0 months with 1-, 3-, and 5-year RFS rate was 83.2%, 59.8%, and 44.6%, respectively. Univariate analysis showed that elevation of carcinoembrionic antigen (CEA), lymph node involvement, resection margin status, degree of periductal invasion, and positive expression of CK20 were associated with both OS and RFS of m-IPNB. After multivariate Cox models analysis, lymph node involvement and positive expression of CK20 were identified as independent prognostic factors for OS, while lymph node involvement and resection margin status were independent prognostic factors for RFS. The median OS of patients with m-IPNB involving lymphatic metastases and positive expression of CK20 was 27.0±8.8 months and 51.0±12.4 months, respectively. The median RFS of cases with lymph node involvement and R1 resection was 10.0±3.3 months and 25.0±6.9 months, respectively. However, there was no significant difference in OS or RFS between cases of pancreaticobiliary and intestinal subtype. Conclusions. Lymph node involvement and positive expression of CK20 are independent prognostic factors for shorter OS of m-IPNB, while patients with lymph node involvement and positive resection margin are at higher risk of tumor recurrence.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.doihttps://doi.org/10.14670/HH-18-179
dc.identifier.eisbnHistology and Histopathology Vol. 35, nº5 (2020)es
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/125686
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCK20es
dc.subjectLymph nodees
dc.subjectPapillary neoplasmes
dc.subjectBile ductes
dc.subjectPrognostic factorses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleCK20 and lymph node involvement predict adverse outcome of malignant intraductal papillary neoplasm of the bile ductes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35, nº5 (2020)