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Regulation mechanisms for the heterodimeric transcription factor, PEBP2lCBF

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dc.contributor.authorBae, S.C.es
dc.contributor.authorIto, Y.es
dc.date.accessioned2011-02-22T11:09:48Z
dc.date.available2011-02-22T11:09:48Z
dc.date.issued1999
dc.description.abstractMembers of the new PEBP2 (Polyomavirus Enhancer Binding Protein 2) family of heterodimeric transcriptional regulatory protein are composed of two subunits, a and B. One of the genes encoding the a subunit, AMLlIPEBP2aB, was identified at the breakpoints of various chromosome translocations, including t(8;21) and t(12;21) associated with acute myeloid leukemia and acute lymphoblastic leukemia, respectively. The gene encoding the B subunit (PEBP2flCBFB) was also shown to be the target of the inversion of chromosome 16, another chromosomal anomaly associated with acute myeloid leukemia. Targeted disruption of either the AmlllPebp2aB or PebpZflICbfb gene resulted in strikingly similar phenotypes such as lack of definitive hematopoiesis of the fetal liver and accompanying hemorrhage of the central nervous system. These observations suggest that both a and l3 subunits of PEBP2 are indispensable for its in vivo function. However, the heterodimerization of the a and B subunit does not seem to occur readily suggesting that their capacity to associate might be an important rate limiting step in PEBP2 site-dependent transcription regulation. In this review, we concentrate on the possible regulatory mechanisms of PEBP2 activity in relation to leukemogenesis.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19230
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectHematopoiesises
dc.subjectLeukemiaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleRegulation mechanisms for the heterodimeric transcription factor, PEBP2lCBFes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.14, nº 4 (1999)