Publication: Plasticity and regulation of human bone marrow stromal osteoprogenitor cells: potential
implication in the treatment of age-related bone loss
Authors
Ahdjoudj, S. ; Fromigué, O. ; Marie, P.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Human bone marrow stroma contains
pluripotent mesenchymal progenitor cells that can give
rise to many mesenchymal lineages, including
chondroblasts, adipocytes or osteoblasts. The
differentiation of these cells towards a specific lineage is
dependent on hormonal and local factors activating
specific transcription factors. Attempts have been
recently made to identify osteoprogenitor cells in the
human bone marrow and to identify the molecular
mechanisms responsible for lineage-specific
differentiation of human bone marrow stromal cells.
Using a clonal pluripotent human bone marrow stromal
cell line with tri-potential characteristics, we have
provided evidence for a controlled reciprocal regulation
of osteoblast/chondroblast and osteoblast/adipocyte
differentiation of human bone marrow stromal cells. We
have also shown that administration of TGFß that
regulates the expression of specific osteoblast and
adipocyte transcription factors can promote osteoblast
differentiation and inhibit adipocyte conversion of rat
marrow stromal cells in vivo. This indicates that the
reciprocal relationship between osteoblastogenesis and
adipogenesis can be manipulated in vivo in order to
improve bone formation. Future studies will have to
identify key signals for lineage-specific differentiation of
human marrow stromal cells. This may result in the
development of therapeutic strategies to promote the differentiation of these cells towards the osteoblast
lineage and to inhibit excessive bone marrow
adipogenesis associated with aging.
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Citation
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