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Cell adhesion molecules in stromal corneal dystrophies

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dc.contributor.authorNemeth, Gabores
dc.contributor.authorFelszeghy, Szabolcses
dc.contributor.authorKenyeres, Annamaria
dc.contributor.authorSzentmáry, Nora
dc.contributor.authorBerta, Andras
dc.contributor.authorSüveges, Ildiko
dc.contributor.authorMódis, Laszlo
dc.date.accessioned2013-01-18T13:36:18Z
dc.date.available2013-01-18T13:36:18Z
dc.date.issued2008
dc.description.abstractThe aim of the present study was to investigate the expression pattern of different cell adhesion molecules in corneal stromal dystrophies. Fifteen corneal buttons from patients diagnosed with three different types of stromal corneal dystrophies and healthy corneas were investigated. Paraffin embedded sections were stained immunohistochemically with monoclonal antibodies against human intercellular adhesion molecule-1 (ICAM-1), endothelial selectin (Eselectin) and endothelial cadherin (E-cadherin) using the avidin-biotin-peroxidase-complex technique. The sections were compared to normal eye bank controls. In corneas from granular dystrophy patients ICAM-1 was expressed focally in epithelial cells and in keratocytes, and expressed diffusely in endothelial cells. In corneas from macular dystrophy patients diffuse epithelial staining was observed and the stromal and endothelial expression was found to be similar to that of granular dystrophy. In lattice dystrophy, only the epithelial cells and endothelium were intensively positive for ICAM-1. E-selectin was not present on any layer of the corneal specimens. E-cadherin was observed only in the epithelium of all three types of corneal dystrophies. Normal corneas did not express any of the investigated adhesion molecules. We found different expression patterns of adhesion molecules in corneas from stromal dystrophies. Our results suggest that adhesion molecules may be involved in the pathogenesis of corneal stromal dystrophies.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/29719
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectStromal corneal dystrophyes
dc.subjectCell adhesion moleculees
dc.subject.other617 - Cirugía. Ortopedia. Oftalmologíaes
dc.titleCell adhesion molecules in stromal corneal dystrophieses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.23, nº8 (2008)