Publication: The transcription factor Fos, a Janus-type regulator in health and disease
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Date
2009
Authors
Durchdewald, Moritz ; Angel, Peter ; Hess, Jochen
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The immediate early gene product Fos is part
of the activator protein-1 (AP-1) transcription factor and
has been shown to participate in the molecular
mechanisms of cell proliferation, differentiation,
apoptosis, and transformation. The analysis of
genetically modified mice and cells derived thereof has
provided important new insights into its specific
biological functions in development, tissue homeostasis,
and cellular responses to environmental insults.
Moreover, the deregulation of Fos could be linked with a
variety of pathological conditions, including
immunological, skeletal and neurological defects, as
well as oncogenic transformation and tumor progression.
In contrast to the mainstream opinion concerning the
oncogenic function of Fos an increasing number of
experimental reports also describe a tumor-suppressive
function in various cancer types. More recently, altered
Fos expression in cell culture and mouse models
combined with global gene expression analysis
unraveled novel downstream effectors of the Fosregulated
genetic program. Finally, selective inhibition
of its function with a small molecule inhibitor in a
preclinical mouse model of arthritis demonstrated that
targeting Fos/AP-1 activity could be an auspicious new
option for clinical use.
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