Targeting the methionine cycle for melanoma therapy with 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin

Rodríguez López, José Neptuno; Sánchez del Campo Ferrer, Luis

Publication:
Targeting the methionine cycle for melanoma therapy with 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin

dc.contributor.author	Rodríguez López, José Neptuno
dc.contributor.author	Sánchez del Campo Ferrer, Luis
dc.contributor.department	Bioquímica y Biología Molecular A	es
dc.date.accessioned	2023-12-22T12:19:26Z
dc.date.available	2023-12-22T12:19:26Z
dc.date.issued	2008-11-15
dc.description	This is an Accepted Manuscript version of the following article, accepted for publication in [International Journal of Cancer]. [Sánchez-del-Campo L, Rodríguez-López JN. Targeting the methionine cycle for melanoma therapy with 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin. Int J Cancer. 2008 Nov 15;123(10):2446-55. doi: 10.1002/ijc.23813.]. It is deposited under the terms of the Creative Commons Attribution-Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited.	es
dc.description	©2008. This manuscript version is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc/4.0/ This document is the Accepted version of a Published Work that appeared in final form in International Journal of Cancer (IJC). To access the final edited and published work see https://doi.org/ 10.1002/ijc.23813	es
dc.description.abstract	The higher expression of methionine cycle genes in melanoma cells than in normal melanocytes may be related with increased protein synthesis and transmethylation reactions and the subsequent need for high levels of methionine. 3-O-(3,4,5-trimethoxybenzoyl)-(-)epicatechin (TMECG), a trimethoxy derivative of epicatechin-3-gallate (ECG), effectively suppressed proliferation of melanoma cells in cultures by inducing apoptosis. TMECG modulates the expression of genes involved in methionine metabolism, cellular methylation and glutathione synthesis in.,melanoma cells. TMECG treatment of melanoma cells resulted in the downregulation of antiapoptotic Bcl-2, the upregulation of proapoptotic Bax and the activation of caspase-3; however, it did not induce the expression of the apoptosis protease-activating factor-1 (Apaf-1). Having elucidated the effects of TMECG on the melanoma methionine cycle, we designed therapeuthical strategies to increase its effectiveness. Combinations of TMECG with S-adenosylmethionine or compounds that modulate the intracellular concentration of adenosine strongly increase the anti proliferative effects of TMECG. The ability of TMECG to target multiple aspects related with melanoma survival, with a high degree of potency, points to its clinical value in melanoma therapy.	es
dc.format	application/pdf	es
dc.format.extent	34	es
dc.identifier.citation	International Journal of Cancer (IJC). Volumen123. Inº10. Paginas 2446-2455
dc.identifier.doi	https://doi.org/ 10.1002/ijc.23813
dc.identifier.issn	0020-7136
dc.identifier.issn	1097-0215
dc.identifier.uri	http://hdl.handle.net/10201/136893
dc.language	eng	es
dc.publisher	WILEY	es
dc.relation	Ámbito del proyecto: Nacional y regional. Agencia financiadora: Ministerio de Educación y Ciencia. Fundación Séneca (CARM) Código o número del acuerdo de subvención: SAF2006-07040-C02-01	es
dc.relation.isreplacedby	10.1002/ijc.23813	es
dc.relation.publisherversion	https://doi.org/10.1002/ijc.23813	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Fólico	es
dc.subject	Melanoma	es
dc.subject	Cancer	es
dc.subject	Adenosine	es
dc.subject	Acido	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísica	es
dc.title	Targeting the methionine cycle for melanoma therapy with 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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